Fig. 1

Relationship between CYP3A4 activity and serum clarithromycin or its metabolite concentrations for the initial period. Time course of serum concentrations of clarithromycin (CAM, ○), 14-hydroxy-CAM (M-5, △), and urinary 6β-hydroxycortisol/cortisol (6βOHF/F, ♦) ratio up to day 29 (n = 9, mean ± SE). *P <0.05 compared with each initial value