Fig. 2

Relationship between CYP3A4 activity and serum rifampicin or its metabolite concentrations for the initial period. Time course of serum concentrations of rifampicin (RFP, □) and 25-desacetyl-RFP (DR, ◊), and the ratio of urinary 6β-hydroxycortisol/cortisol (6βOHF/F, ♦) up to day 29 (n = 9, mean ± SE). *P < 0.05 compared with each initial value