Fig. 3

Long-term changes of CYP3A4 activity and serum clarithromycin or its metabolite concentrations. Time course of serum concentration of clarithromycin (CAM, ○) and 14-hydroxy-CAM (M-5, △), and the ratio of urinary 6β-hydroxycortisol/cortisol (6βOHF/F, ♦) up to the day 365 (n = 4, mean ± SE)