Fig. 4

Long-term changes of CYP3A4 activity and serum rifampicin or its metabolite concentrations. Time course of serum concentration of rifampicin (RFP, □) and 25-desacetyl-RFP (DR, ◊), and ratio of urinary 6β-hydroxycortisol/cortisol (6βOHF/F, ♦) up to day 365 (n = 4, mean ± SE)