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| |
Total (n = 10)
|
Everolimus blood concentration just before discontinuation or dose reduction (ng/mL)
|
|---|
|
≤ 15.3 (n = 5)
|
> 15.3 (n = 5)
|
|---|
| |
All grades
|
Grade 3 or 4
|
All grades
|
Grade 3 or 4
|
All grades
|
Grade 3 or 4
|
|
Number of patients
|
|
Any event
|
8
|
5
|
3
|
2
|
5
|
3
|
|
Fatigue
|
1
|
0
|
0
|
0
|
1
|
0
|
|
Nausea
|
1
|
0
|
0
|
0
|
1
|
0
|
|
Vomiting
|
1
|
0
|
0
|
0
|
1
|
0
|
|
Mucosal inflammation
|
5
|
0
|
2
|
0
|
3
|
0
|
|
Diarrhea
|
1
|
0
|
0
|
0
|
1
|
0
|
|
Rash
|
2
|
0
|
1
|
0
|
1
|
0
|
|
Pneumonitis
|
4
|
2
|
2
|
1
|
2
|
1
|
|
Increased aspartate aminotransferase
|
2
|
0
|
0
|
0
|
2
|
0
|
|
Increased alanine transaminase
|
2
|
0
|
0
|
0
|
2
|
0
|
|
Increased alkaline phosphatase
|
3
|
0
|
0
|
0
|
3
|
0
|
|
Increased γ-glutamyltransferase
|
1
|
1
|
0
|
0
|
1
|
1
|
|
Leukopenia
|
3
|
2
|
1
|
1
|
2
|
1
|
|
Neutropenia
|
2
|
0
|
1
|
0
|
1
|
0
|
|
Thrombocytopenia
|
2
|
0
|
0
|
0
|
2
|
0
|
|
Anemia
|
2
|
0
|
0
|
0
|
2
|
0
|
|
Hypoalbuminemia
|
1
|
1
|
0
|
0
|
1
|
1
|
|
Hyperglycemia
|
2
|
1
|
0
|
0
|
2
|
1
|
