Table 3 Summary statistics of fluconazole serum concentrations after intravenous fosfluconazole administration
From: A sensitive method for analyzing fluconazole in extremely small volumes of neonatal serum
| Parameters | Value | |
|---|---|---|
| Number of neonates (male/female) | 10 (6/4) | |
| Number of scavenged sampling points | 234 | |
| Sample volume | < 25 μL | 208 |
| ≥ 25 μL | 26 | |
| Median gestational age (weeks, range) | 28.5 (23.3–33.4) | |
| Median weight (g, range) | 765 (470–1000) | |
| Median height (cm, range) | 33.0 (28.0–38.0) | |
| Median fluconazole dose (mg/kg/dose, range) | 3.1 (2.7–3.7) | |
| Sample from arterial lines (n = 178) | Median time after dose (hour, range) | 43.7 (0.5–479.7) |
| Median concentration (μg/mL, range) | 2.8 (< 0.01–26.8) | |
| Sample from heel-sticks (n = 56) | Median time after dose (hour, range) | 40.0 (0.4–467.4) |
| Median concentration (μg/mL, range) | 3.3 (< 0.01–25.9) |