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Characteristics
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All patients (n=70)
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Diarrhea (+) (n=22)
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Diarrhea (−) (n=48)
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P value
|
|---|
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Age (years)
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67 [30–85]
|
63 [37–81]
|
67 [30–85]
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0.714
|
|
Female
|
30 (43)
|
13 (59)
|
17 (36)
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0.074
|
|
Body weight (kg)
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52.5 [31.0–76.8]
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51.3 [38.6–72.6]
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54.6 [31.0–76.8]
|
0.786
|
|
CCr (mL/min)
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67.5 [5.1–140.0]
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71.5 [27.7–120.5]
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63.0 [5.1–140.0]
|
0.305
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Performance status (3–4)
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12 (17)
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6 (27)
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6 (13)
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0.174
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|
NAL dose (μg/kg)
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3.8 [2.6–6.5]
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3.9 [2.8–5.2]
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3.7 [2.6–6.5]
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0.849
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Opioid dose (morphine base, mg)
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17.5 [2.5–390.0]
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30.0 [7.5–390.0]
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15.0 [2.5–180.0]
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0.094
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Duration of opioid therapy before NAL administration (day)
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6 [0–1365]
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27 [0–1365]
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4 [0–268]
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0.002
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Co-administrated drugs
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|
Drugs with risk of constipation
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61 (87)
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19 (86)
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42 (88)
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1.000
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PPI or H2-blocker
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49 (70)
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18 (82)
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31 (65)
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0.171
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Laxative
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58 (83)
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20 (91)
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38 (79)
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0.316
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Oral anticancer drug
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13 (19)
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6 (27)
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7 (15)
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0.320
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Intravenous anticancer drug
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30 (43)
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10 (45)
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20 (42)
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0.800
|
|
Antimicrobial agent
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36 (51)
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12 (55)
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24 (50)
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0.800
|
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Tubal feeding
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5 (7)
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2 (9)
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3 (6)
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0.646
|
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Opioid analgesics
|
|
Oxycodone
|
49 (70)
|
16 (73)
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33 (69)
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0.787
|
|
Morphine
|
3 (4)
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0 (0)
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3 (6)
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0.547
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Fentanyl
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7 (10)
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4 (18)
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3 (6)
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0.195
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|
Tramadol
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9 (13)
|
1 (5)
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8 (17)
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0.255
|
|
Methadone
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1 (1)
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1 (5)
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0 (0)
|
0.314
|
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Hydromorphone
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1 (1)
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0 (0)
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1 (2)
|
1.000
|
|
Primary tumor
|
|
Pancreatic
|
12 (17)
|
6 (27)
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6 (13)
|
0.174
|
|
Head and neck
|
8 (11)
|
2 (9)
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6 (13)
|
1.000
|
|
Lung
|
6 (9)
|
2 (9)
|
4 (8)
|
1.000
|
|
Breast
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5 (7)
|
1 (5)
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4 (8)
|
1.000
|
|
Soft tissue
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5 (7)
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0 (0)
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5 (10)
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0.173
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Hepatic
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4 (6)
|
2 (9)
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2 (4)
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0.585
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Stomach
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3 (4)
|
1 (5)
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2 (4)
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1.000
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Colorectal
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2 (3)
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0 (0)
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2 (4)
|
1.000
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|
Others and non-cancer
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25 (36)
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8 (36)
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17 (35)
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1.000
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- Values are presented as median [range] or number (%)
- CCr Creatinine clearance, NAL Naldemedine, PPI Proton-pump inhibitor
