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total a)
|
Hyperprolactinemia
|
|---|
|
n
|
ROR (95%CI)
|
PRR (X2)
|
IC (95%CI)
|
|---|
|
Typical antipsychotic
|
| |
Haloperidol
|
939
|
3
|
81.79 (25.76, 259.68)*
|
80.89 (158.65)*
|
1.95 (−1.47, 5.36)
|
|
Bromperidol
|
113
|
0
|
–
|
–
|
–
|
|
Pipamperone
|
15
|
0
|
–
|
–
|
–
|
|
Spiperone
|
0
|
0
|
–
|
–
|
–
|
|
Timiperone
|
9
|
0
|
–
|
–
|
–
|
|
Propericiazine
|
85
|
0
|
–
|
–
|
–
|
|
Prochlorperazine
|
143
|
0
|
–
|
–
|
–
|
|
Perphenazine
|
17
|
0
|
–
|
–
|
–
|
|
Fluphenazine
|
89
|
4
|
149.56 (54.48, 410.63)*
|
146.59 (424.31)*
|
2.28 (−0.80, 5.36)
|
|
Levomepromazine
|
730
|
0
|
–
|
–
|
–
|
|
Chlorpromazine
|
431
|
0
|
–
|
–
|
–
|
|
Sulpiride
|
1395
|
13
|
283.29 (156.78, 511.89)*
|
273.74 (2840.96)*
|
3.73 (1.81, 5.65)*
|
|
Sultopride
|
52
|
0
|
–
|
–
|
–
|
|
Nemonapride
|
9
|
0
|
–
|
–
|
–
|
| |
Pimozide
|
39
|
0
|
–
|
–
|
–
|
|
Atypical antipsychotic
|
| |
Perospirone
|
416
|
0
|
–
| | |
|
Risperidone
|
2629
|
13
|
190.01 (105.46–342.34)*
|
185.67 (1919.94)*
|
3.69 (1.78, 5.61)*
|
|
Paliperidone
|
774
|
23
|
1187.33 (728.48,1935.18)*
|
1050.90 (17,778.71)*
|
4.54 (2.96, 6.12)*
|
|
Blonanserin
|
550
|
5
|
184.22 (74.16, 457.61)*
|
179.78 (683.21)*
|
2.54 (−0.29, 5.37)
|
|
Olanzapine
|
1825
|
4
|
60.79 (22.27, 165.95)*
|
60.30 (170.62)*
|
2.22 (−0.83, 5.28)
|
|
Quetiapine
|
1836
|
1
|
15.24 (2.12,109.53)*
|
15.21 (2.84)
|
0.91 (−3.85, 5.66)
|
|
Clozapine
|
1283
|
0
|
–
|
–
|
–
|
|
Asenapine
|
134
|
2
|
188.96 (45.76, 780.12)*
|
184.14 (200.09)
|
1.57 (−2.39, 5.53)
|
|
Aripiprazole
|
2316
|
0
|
–
|
–
|
–
|
|
Brexpiprazole
|
112
|
0
|
–
|
–
|
–
|
|
Zotepine
|
279
|
0
|
–
|
–
|
–
|
|
Mosapramine
|
4
|
0
|
–
|
–
|
–
|
|
Oxypertine
|
6
|
0
|
–
|
–
|
–
|
|
Clocapramine
|
0
|
0
|
–
|
–
|
–
|
- ROR: the reporting odds ratio, PRR: the proportional reporting ratio, IC: the information component, CI: the confidence interval
- a) total number of reports from April 2004 to April 2019 in JADER
- An asterisk(*) indicates that the adverse events are detected as signals
