Articles

Pharmacoepidemiology in Japan: medical databases and research achievements

Pharmacoepidemiology involves development of new models to predict safety in the development stages of pharmaceutical products, development of various guidelines and policy related to clinical trials, pharmaco...

Authors: Shiro Tanaka, Kahori Seto and Koji Kawakami

Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports

Antipsychotics are potent dopamine antagonists used to treat schizophrenia and bipolar disorder. The aim of this study was to evaluate the relationship between antipsychotic drugs and adverse hyperglycemic eve...

Authors: Yamato Kato, Ryogo Umetsu, Junko Abe, Natsumi Ueda, Yoko Nakayama, Yasutomi Kinosada and Mitsuhiro Nakamura

Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration...

Authors: Masayuki Hashiguchi, Yuriko Ohta, Mikiko Shimizu, Junya Maruyama and Mayumi Mochizuki

Onset of analgesia with ibuprofen sodium in tension-type headache: a randomized trial

Ibuprofen is known to be efficacious in the treatment of tension-type headache, the most common form of primary headache. A novel tablet formulation of ibuprofen sodium is more rapidly absorbed than standard i...

Authors: Elias Packman, Rina Leyva and David Kellstein

Adherence to changing from brand-name to generic atorvastatin in newly treated patients: a retrospective cohort study using health insurance claims

Effect of statin therapy has been reported to be associated with patient’s adherence. Atorvastatin was available in Japan as a brand-name product beginning in 2000. The first atorvastatin generics were introdu...

Authors: Yasunari Mano, Shota Fukushima, Hisayuki Kuroda, Hiroyuki Ohshima, Yoshinori Kato, Kaori Ohuchi, Kayoko Maezawa, Yasuyuki Momose, Shunya Ikeda and Mariko Asahi

Relationship between incident types and impact on patients in drug name errors: a correlational study

There are many reports regarding various medical institutions’ attempts at incident prevention, but the relationship between incident types and impact on patients in drug name errors has not been studied. Ther...

Authors: Toshikazu Tsuji, Toshihiro Irisa, Shunichi Ohata, Chiyo Kokubu, Akiko Kanaya, Masanori Sueyasu, Nobuaki Egashira and Satohiro Masuda

Supersaturated state of diazepam injection following dilution with infusion fluid

Significant precipitation produced by the dilution of diazepam (DZP) injection with an infusion fluid is a great concern for the clinical practice. In this study, the precipitation behavior under different con...

Authors: Yoshinori Onuki, Naoki Hasegawa, Chihiro Kida, Mayumi Ikegami-Kawai, Masayoshi Tsubuki, Shunsuke Shirozu, Yasuko Obata and Kozo Takayama

Pharmacoeconomic effect of compliance with pharmacist’s intervention based on cancer chemotherapy regimens: a cohort study

It is important for pharmacists to manage cancer chemotherapy regimens in order to achieve safe treatment. We examined whether there was a useful pharmacoeconomic benefit of compliance the exclusion criteria o...

Authors: Makoto Hayashi, Akimasa Yamatani, Hiromu Funaki and Kenichi Miyamoto

Correlation of plasma crizotinib trough concentration with adverse events in patients with anaplastic lymphoma kinase positive non-small-cell lung cancer

Crizotinib, an ATP-competitive receptor tyrosine kinase inhibitor of both anaplastic lymphoma kinase (ALK) and the hepatocyte growth factor receptor, commonly causes several adverse events (AEs). The clinical ...

Authors: Yasuko Kurata, Narumi Miyauchi, Manabu Suno, Takahiro Ito, Toshiaki Sendo and Katsuyuki Kiura

Effectiveness of medical supportive team for outpatients treated with sorafenib: a retrospective study

It is well known that molecular-targeted drugs, of which sorafenib (Nexavar®) is one, differ from previous anticancer drugs and cause various unusual adverse drug reactions. Treatment with sorafenib causes adv...

Authors: Makoto Kajizono, Megumu Aoyagi, Yoshihisa Kitamura and Toshiaki Sendo

Prescription rate of medications potentially contributing to lower urinary tract symptoms and detection of adverse reactions by prescription sequence symmetry analysis

The lower urinary tract symptoms (LUTS) increases with age and can have a significant effect on the quality of life of the patients. Elderly patients, who are often characterized by a decline in physiological ...

Authors: Masako Hashimoto, Kanako Hashimoto, Fumihiko Ando, Yoshiaki Kimura, Keisuke Nagase and Kunizo Arai

Photostability studies on (±)-tramadol in a liquid formulation

Tramadol ((±)-TRA) is recommended for the treatment of mild to moderate cancer pain by the World Health Organization. An oral liquid formulation of (±)-TRA is preferable for patients with a compromised swallow...

Authors: Manabu Suno, Hidenori Ichihara, Takahiro Ishino, Kento Yamamoto and Yuta Yoshizaki

Clinical risk factors associated with postoperative delirium and evaluation of delirium management and assessment team in lung and esophageal cancer patients

Delirium is an acute change in cognition and concentration that complicates the postoperative course. Patients who suffer delirium after surgery have an increased risk of persistent cognitive impairment, funct...

Authors: Kiminaka Murakawa, Yoshihisa Kitamura, Saori Watanabe, Shiho Hongo, Kazuaki Shinomiya and Toshiaki Sendo

Expected value of the additional state in evaluating the method of quantification and uncertainty of additional states in an analytical model of grade I hypertension

In the construction of pharmacoeoconomic models, simplicity is desirable for transparency (people can see how the model is built), ease of analysis, validation (how well the model reproduces reality), and desc...

Authors: Takeshi Uchikura, Makoto Kobayashi, Masayuki Hashiguchi and Mayumi Mochizuki

Pharmacist-managed clinics for patient education and counseling in Japan: current status and future perspectives

To improve the adherence to and knowledge about pharmacotherapy in outpatients and to maximize the efficacy and minimize the adverse drug events, the first pharmacist-managed clinic (PMC) in Japan was establis...

Authors: Kiyofumi Yamada and Toshitaka Nabeshima

Journal of pharmaceutical health care and sciences

Authors: Toshiya Katsura